Past Event: Oden Institute Seminar

A Medical Digital Twin for the Gut Microbiome

Leo Grady, Founder and CEO, Jona, Inc.

Abstract

The gut microbiome has been demonstrated to broadly underpin human health from digestive disorders and autoimmune disease to obesity, cancer, drug efficacy, cardiometabolic disease, liver disease, human longevity, fertility, Parkinson’s Disease, autism and even mental health.  Furthermore, the gut microbiome is modifiable through diet, lifestyle and medication which offers the possibility of new treatment strategies for these health conditions. Yet, so far the gut microbiome has been too complex and the science too fast moving to benefit individuals, doctors and innovators in practice.  For the first time, Large Language Models have made it possible to draw together the entirety of both the medical literature and the scientific literature to both analyze a person’s gut microbiome data in the context of all the latest knowledge and also to calculate the impact of a wide variety of different interventions (over 4000 different interventions) using a medical digital twin.  In this talk we describe the custom AI used to extract the microbiome analysis and interventional knowledge from the literature, how that knowledge is applied to create a microbiome digital twin and how these technologies have been deployed for clinical use today.

Biography

Leo is internationally recognized for his work to deliver AI in health for over 20 years at pioneering bay area startups (HeartFlow), multinational medical companies (Siemens) and as CEO of Paige.ai. As CEO of Paige, Leo led the company to become an industry leader, internationally launching groundbreaking products and receiving the first-ever FDA approval for an AI product in pathology. Leo’s new company, Jona, has developed a unique AI and digital twin to both analyze and change the gut microbiome to significantly improve health.  Leo has authored two books on AI, over 100 peer-reviewed scientific papers and is an inventor on over 300 patents. Winner of the Edison Patent Award, he was inducted as Fellow in the American Institute for Medical and Biological Engineering. Leo earned a Ph.D. in Cognitive and Neural Systems from Boston University.  Leo is CEO in Residence with Breyer Capital and the Founder and CEO of Jona.